Iwasa H, Mimura K, Ohsaki Y, Kanabe S, Hiraide H, Mizoguchi O, Tamaki K, Kurokawa T, Hatsuse K, Kadota T, Ezoe I, Tsuru S, Zinnaka Y
Gan To Kagaku Ryoho. 1983 Feb;10(2 Pt):254-60.
The effects of a combined chemotherapy of solcoseryl and FT-207 on tumor growth, delayed hypersensitivity and cell population of the spleen were studied using inbred BALB/c mice. Meth-A tumor cells (2 X 10(6] were inoculated into the back of 5 to 6 week old BALB/c male mouse. Animals were divided into three groups: Solcoseryl group, in which 0.04 mg of solcoseryl was injected intravenously three times before inoculation and four times after inoculation; Combined group, in which 1.2 mg of FT-207 and 0.04 mg of solcoseryl were injected intravenously four times after inoculation; FT-207 group, in which 1.2 mg of FT-207 was injected four times after inoculation, with out solcoseryl administration. Following results were obtained: Solcoseryl group showed enhanced immunity and tumor suppression; Decreased immunity due to FT-207 was recovered by administration of solcoseryl but no tumor suppression was observed and, Decreased T-cell population of spleen due to FT-207 was recovered by administration of solcoseryl. These facts suggested that solcoseryl was useful because of making recovery possible from decreased immunity due to chemotherapy.
利用近交系BALB/c小鼠，研究了舒康博和替加氟联合化疗对肿瘤生长、迟发型超敏反应及脾脏细胞群体的影响。将Meth-A肿瘤细胞（2×10⁶）接种到5至6周龄BALB/c雄性小鼠的背部。动物分为三组：舒康博组，接种前静脉注射0.04mg舒康博3次，接种后静脉注射4次；联合组，接种后静脉注射1.2mg替加氟和0.04mg舒康博4次；替加氟组，接种后静脉注射1.2mg替加氟4次，不给予舒康博。获得以下结果：舒康博组显示出免疫增强和肿瘤抑制作用；替加氟导致的免疫下降通过给予舒康博得以恢复，但未观察到肿瘤抑制作用，且替加氟导致的脾脏T细胞群体减少通过给予舒康博得以恢复。这些事实表明，舒康博是有用的，因为它能够使因化疗导致的免疫下降得以恢复。
