Kurokawa T, Iwasa H, Mimura K, Terashima H, Hiraide H, Mizoguchi O, Kanabe S, Tamaki K, Kadota T, Hatsuse K
Gan To Kagaku Ryoho. 1984 Apr;11(4):881-7.
The peritoneal surface of the lesion was observed after treatment by scanning electron microscopy to evaluate the anticancer effect of FT-207. FT-207 (1.0 mg/day) was injected intraperitoneally to the DDN mice in which 3 X 10(7) MM2 tumor cells were inoculated the day before treatment. The anticancer effect was examined from 2nd to 7th consecutive day after tumor cell implantation, and the following results were obtained. 1) In the early phase after injection of FT-207, many macrophage-like cells were observed on the peritoneal surface. 2) Each MM2 tumor cell was covered by many macrophage-like cells, and these tumor cells were destroyed. 3) In the late phase after injection of FT-207, tumor cells were hyperplastic on the peritoneal surface, but less prominent than in the control group. 4) Effusion and adhesion in peritonitis carcinomatosa of FT-207 group were less than in the control group.
治疗后，通过扫描电子显微镜观察病变的腹膜表面，以评估FT - 207的抗癌效果。将FT - 207（1.0毫克/天）腹腔注射到治疗前一天接种了3×10⁷个MM2肿瘤细胞的DDN小鼠体内。在肿瘤细胞植入后的第2天至第7天连续检查抗癌效果，获得以下结果。1）在注射FT - 207后的早期，在腹膜表面观察到许多巨噬细胞样细胞。2）每个MM2肿瘤细胞都被许多巨噬细胞样细胞覆盖，并且这些肿瘤细胞被破坏。3）在注射FT - 207后的晚期，腹膜表面的肿瘤细胞增生，但不如对照组明显。4）FT - 207组的癌性腹膜炎中的积液和粘连少于对照组。
