Formation of electrophilic chlorine from carbon tetrachloride--involvement of cytochrome P-450. - Suppr | 超能文献

Formation of electrophilic chlorine from carbon tetrachloride--involvement of cytochrome P-450.

作者信息

Mico B A, Branchflower R V, Pohl L R

出版信息

Biochem Pharmacol. 1983 Aug 1;32(15):2357-9. doi: 10.1016/0006-2952(83)90188-0.

DOI:10.1016/0006-2952(83)90188-0

Abstract

摘要

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Formation of electrophilic chlorine from carbon tetrachloride--involvement of cytochrome P-450.

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Metabolism of carbon tetrachloride to electrophilic chlorine by liver microsomes: exclusion of cytochrome P-450 catalyzed chloroperoxidase reaction.肝脏微粒体将四氯化碳代谢为亲电子氯：排除细胞色素P-450催化的氯过氧化物酶反应。

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Activation of carbon tetrachloride, and distribution of NADPH-cytochrome c reductase, cytochrome P-450, and other microsomal enzyme activities in rat tissues.四氯化碳的活化以及大鼠组织中NADPH-细胞色素c还原酶、细胞色素P-450和其他微粒体酶活性的分布。

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Isoflurane enhances dechlorination of carbon tetrachloride in guinea-pig liver microsomes.异氟烷可增强豚鼠肝微粒体中四氯化碳的脱氯作用。

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Cytochrome P-450-dependent formation of reactive oxygen radicals: isozyme-specific inhibition of P-450-mediated reduction of oxygen and carbon tetrachloride.细胞色素P - 450依赖性活性氧自由基的形成：P - 450介导的氧还原和四氯化碳的同工酶特异性抑制作用

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Carbon tetrachloride activation, lipid peroxidation, and the mixed function oxygenase activity of various rat tissues.四氯化碳激活、脂质过氧化以及大鼠各种组织的混合功能氧化酶活性。

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Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: role of cytochrome P-450.四氯化碳、氯仿和溴三氯甲烷的生物活化作用：细胞色素P-450的作用

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The drug methoxsalen, a suicide substrate for cytochrome P-450, decreases the metabolic activation, and prevents the hepatotoxicity, of carbon tetrachloride in mice.

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Modification of carbon tetrachloride hepatotoxicity by chemicals.

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