Goodridge D M, Shorvon S D
Br Med J (Clin Res Ed). 1983 Sep 3;287(6393):645-7. doi: 10.1136/bmj.287.6393.645.
Treatment and prognosis were studied in 122 patients with non-febrile seizures in a population of 6000. Phenytoin and phenobarbitone were the most commonly prescribed drugs, although the popularity of phenobarbitone had declined over time. The average duration of treatment was relatively short, and most patients received single drug treatment. Treatment patterns were erratic, and the surveillance and audit of treatment generally poor. Recurrence after a first attack was found in four fifths of the patients. Generally the total number of seizures suffered by each patient was small, the period of active epilepsy short, and remission when it occurred was usually permanent. The cumulative probability of continuing activity fell and the proportion of patients in remission rose over time. Patients with partial or mixed seizure types had a poorer overall prognosis. The course of the epilepsy in the early years of treatment proved to be a useful guide to the long term prognosis, and the possibility that effective treatment might influence long term prognosis is raised.
在一个6000人的群体中，对122例无热惊厥患者的治疗和预后进行了研究。苯妥英钠和苯巴比妥是最常用的药物，不过苯巴比妥的使用频率随时间有所下降。治疗的平均持续时间相对较短，大多数患者接受单药治疗。治疗模式不稳定，治疗的监测和审核普遍较差。五分之四的患者首次发作后复发。一般来说，每位患者发作的总数较少，活动性癫痫发作期较短，缓解一旦出现通常是永久性的。随着时间推移，持续发作的累积概率下降，缓解患者的比例上升。部分发作或混合发作类型的患者总体预后较差。治疗早期癫痫的病程被证明是长期预后的有用指南，并且提出了有效治疗可能影响长期预后的可能性。
