甲型血友病突变率性别比的最大似然估计。
A maximum likelihood estimate of the sex ratio of mutation rates in haemophilia A.
作者信息
Winter R M, Tuddenham E G, Goldman E, Matthews K B
出版信息
Hum Genet. 1983;64(2):156-9. doi: 10.1007/BF00327115.
PMID:6411604
Abstract
Carrier detection tests were carried out on 21 mothers of isolated cases of severe Haemophilia A, according to WHO recommendations. A maximum likelihood estimate of the male to female mutation ratio of 9.6 (95% confidence limits 2.2-41.5) was obtained.
摘要
根据世界卫生组织的建议，对21名重度甲型血友病孤立病例的母亲进行了携带者检测。得出男性与女性突变率的最大似然估计值为9.6（95%置信区间为2.2 - 41.5）。
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