Harach H R, Jasani B, Williams E D
J Clin Pathol. 1983 Sep;36(9):1050-4. doi: 10.1136/jcp.36.9.1050.
Factor VIII-related antigen is a recognised marker of endothelial cells. A brief immunocytochemical study of its distribution in follicular carcinoma of the thyroid and its value in the recognition of vascular invasion by this tumour has been carried out. Ten cases of follicular carcinoma of the thyroid were studied. In each strong endothelial staining was found in the majority of vessels in the adjacent normal thyroid. Lymphatic endothelium was negative. In eight of the 10 cases the staining of vessels within the tumour was absent or very weak. Staining was also absent in the majority of vessels completely occluded by tumour, but was present in the endothelium of vessels only partly occluded by tumour. It is concluded that factor VIII-related antigen staining has only limited value in the recognition of vascular invasion in follicular carcinoma. The absence of vascular staining in the tumour leads us to suggest that inhibition of factor VIII production by the tumour could be a possible mechanism which facilitates vascular invasion and metastasis.
血管内皮生长因子相关抗原是公认的内皮细胞标志物。本文对其在甲状腺滤泡癌中的分布及其在识别该肿瘤血管侵犯方面的价值进行了简要的免疫细胞化学研究。研究了10例甲状腺滤泡癌。在每例中，相邻正常甲状腺的大多数血管中均发现强烈的内皮染色。淋巴管内皮呈阴性。10例中有8例肿瘤内血管染色缺失或非常微弱。大多数被肿瘤完全阻塞的血管也无染色，但在仅被肿瘤部分阻塞的血管内皮中存在染色。结论是，血管内皮生长因子相关抗原染色在识别滤泡癌血管侵犯方面价值有限。肿瘤中血管染色的缺失使我们推测，肿瘤抑制血管内皮生长因子的产生可能是促进血管侵犯和转移的一种可能机制。
