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1
Posttransfusion non-A, non-B hepatitis: physicochemical properties of two distinct agents.输血后非甲非乙型肝炎：两种不同病原体的理化特性
J Infect Dis. 1983 Aug;148(2):254-65. doi: 10.1093/infdis/148.2.254.
2
Posttransfusion non-A, non-B hepatitis in chimpanzees. Physicochemical evidence that the tubule-forming agent is a small, enveloped virus.黑猩猩的输血后非甲非乙型肝炎。形成小管因子为一种小型包膜病毒的物理化学证据。
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4
Inactivation of hepatitis B virus and non-A, non-B hepatitis by chloroform.氯仿对乙型肝炎病毒及非甲非乙型肝炎病毒的灭活作用
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5
Non-A, non-B hepatitis viruses.非甲非乙型肝炎病毒
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Non-A, non-B hepatitis: ultrastructural evidence for two agents in experimentally infected chimpanzees.非甲非乙型肝炎：实验感染黑猩猩中两种病原体的超微结构证据
Science. 1979 Jul 13;205(4402):197-200. doi: 10.1126/science.451589.
7
Ultrastructural alterations in hepatocytes and sinus endothelia in experimental non-A, non-B hepatitis in chimpanzees with and without immunoglobulin prophylaxis.有或无免疫球蛋白预防措施的黑猩猩实验性非甲非乙型肝炎中肝细胞和肝血窦内皮细胞的超微结构改变
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J Med Virol. 1981;7(1):1-19. doi: 10.1002/jmv.1890070102.

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9
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Viral markers in the treatment of hepatitis B and C.乙型和丙型肝炎治疗中的病毒标志物
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输血后非甲非乙型肝炎：两种不同病原体的理化特性

Posttransfusion non-A, non-B hepatitis: physicochemical properties of two distinct agents.

作者信息

Bradley D W, Maynard J E, Popper H, Cook E H, Ebert J W, McCaustland K A, Schable C A, Fields H A

出版信息

J Infect Dis. 1983 Aug;148(2):254-65. doi: 10.1093/infdis/148.2.254.

DOI:10.1093/infdis/148.2.254
PMID:6411832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7109850/
Abstract

Two separate and distinct episodes of non-A, non-B hepatitis were induced in each of two chimpanzees by two inocula: one containing a chloroform-resistant agent and the other containing a chloroform-sensitive agent. Both agents were recovered from liver tissue and plasma obtained from a single chimpanzee during the acute and chronic phases of infection with a factor VIII concentrate, respectively. The chloroform-resistant agent did not cause unique changes in hepatocytes; in contrast, the chloroform-sensitive agent did induce the formation of cytoplasmic tubules, convoluted endoplasmic reticulum, and dense reticular inclusion bodies. The latter changes are similar in character to those induced in infected cells by some enveloped mammalian RNA viruses.

摘要

通过两种接种物在两只黑猩猩身上分别引发了两起独立且不同的非甲非乙型肝炎病例

一种接种物含有耐氯仿因子，另一种含有氯仿敏感因子。这两种因子分别从一只感染了凝血因子 VIII 浓缩剂的黑猩猩在感染急性期和慢性期获取的肝脏组织及血浆中分离得到。耐氯仿因子未引起肝细胞的独特变化；相反，氯仿敏感因子确实诱导了细胞质小管、卷曲内质网和致密网状包涵体的形成。后一种变化在特征上与某些包膜哺乳动物 RNA 病毒在受感染细胞中诱导产生的变化相似。