Niksić-Ivancić M, Oresković M
Laryngol Rhinol Otol (Stuttg). 1983 Jun;62(6):246-8.
Alpha-1-antitrypsin was elevated in patients with laryngeal and hypopharyngeal carcinoma and this increase positively correlated with the tumor size. Surgery and radiotherapy (preoperative or primary) caused a statistically significant increase in the activity of this antienzyme. Possibility the inability of the alpha-1-antitrypsin to reactively increase is responsible for the malignant development of some laryngeal tumors which appear relatively benign according to histological findings and their spread. The reactive increase of the alpha-1-antitrypsin is prognostically more important than its momentary blood level. These investigations confirmed the complexity of malignant tumors in not only their development but also their course. The alpha-1-antitrypsin - the inhibitor of the proteolytic enzyme - is one of the factors in the development of the tumor and particularly in its propagation.
α-1抗胰蛋白酶在喉癌和下咽癌患者中升高，且这种升高与肿瘤大小呈正相关。手术和放疗（术前或原发性放疗）导致这种抗酶活性在统计学上显著增加。α-1抗胰蛋白酶无法反应性增加可能是一些根据组织学检查结果及其扩散情况看似相对良性的喉肿瘤发生恶变的原因。α-1抗胰蛋白酶的反应性增加在预后方面比其瞬时血液水平更重要。这些研究证实了恶性肿瘤不仅在其发展过程中而且在其病程中都具有复杂性。α-1抗胰蛋白酶——蛋白水解酶的抑制剂——是肿瘤发展尤其是其扩散的因素之一。
