Jannasch R
Pharmazie. 1983 Jun;38(6):379-87.
Capillary isotachophoresis is presented as an electrokinetic separation and determination method with a wide field of application. Its efficiency meets standards applied to modern chromatographic techniques. The high separation efficiency of capillary isotachophoresis and the double system of detection, that yields two qualitative and quantitative data for each charge carrier zone, allow to consider capillary isotachophoresis to be very suitable for drug analysis. By the example of the peptides saralasin, gonadorelin and protirelin and the corresponding dosage forms, the suitability of the technique for identification, purity and stability tests, as well as for analytical work, is demonstrated. Special aspects of peptide evaluation, especially with regard to the characterization of standard substances, are dealt with.
毛细管等速电泳是一种具有广泛应用领域的电动分离和测定方法。其效率符合现代色谱技术所应用的标准。毛细管等速电泳的高分离效率以及双重检测系统，该系统能为每个带电载体区产生两个定性和定量数据，这使得毛细管等速电泳被认为非常适合药物分析。通过肽类药物沙拉新、促性腺激素释放素和普罗瑞林以及相应剂型的实例，证明了该技术在鉴别、纯度和稳定性测试以及分析工作方面的适用性。文中还讨论了肽类评估的特殊方面，特别是关于标准物质的表征。
