柠檬酸盐对血小板聚集和丙二醛生成的影响。
The influence of citrate on platelet aggregation and malondialdehyde production.
作者信息
Huijgens P C, van den Berg C A, Voetdijk A M, Imandt L M
出版信息
Scand J Haematol. 1983 Aug;31(2):129-32. doi: 10.1111/j.1600-0609.1983.tb01519.x.
3 commonly used parameters for platelet aggregability were tested for their dependence on citrate concentrations. Relatively minor changes in citrate concentrations markedly influenced ADP threshold values for secondary aggregation. Collagen induced platelet malondialdehyde (MDA) production was reduced by increasing the citrate level. This effect was still present in plasma which was also anticoagulated with EDTA. Thrombin induced MDA production was considerably higher in EDTA than in citrate plasma. Citrate appears to inhibit aggregation as well as MDA synthesis. The latter effect does not seem to be solely caused by the effect of citrate on ionized calcium levels.
对血小板聚集性的3个常用参数进行了测试，以考察其对枸橼酸盐浓度的依赖性。枸橼酸盐浓度的相对微小变化显著影响二次聚集的ADP阈值。增加枸橼酸盐水平可降低胶原诱导的血小板丙二醛（MDA）生成。在也用乙二胺四乙酸（EDTA）抗凝的血浆中仍存在这种效应。凝血酶诱导的MDA生成在EDTA血浆中比在枸橼酸盐血浆中高得多。枸橼酸盐似乎抑制聚集以及MDA合成。后一种效应似乎并非仅由枸橼酸盐对离子钙水平的影响所致。
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