[Long-term experience in the therapy and prevention of unspecific vaginal discharge with a Lactobacillus vaccine].

This report presents a study of 28 women with chronic non-specific vaginitis treated by Solco Trichovac, a vaccine containing at least 7 X 10(9) inactivated microorganisms of various strains of Lactobacillus acidophilus in each 0.5 ml dose. 3 injections were administered at 2-week intervals, and the results of therapy investigated with regard to quantitative increase in lactobacilli in the vaginal secretion, change in grade according to Schröder and reduction of the vaginal fluor. The vaccination caused a significant (p less than 0.01) quantitative increase in physiological lactobacilli. Accordingly, there was a significant improvement (p less than 0.01) in grade already 4 weeks after completion of the primary course of treatment. Re-examination after one year showed that nearly 80% of the patients were grade I to II; the vaginal fluor was clinically cured or at least markedly improved in 85.6% of cases. In our experience the vaccination presents a promising new concept of therapy and shows a special effect in patients with chronic non-specific vaginitis and with reduced Döderlein's vaginal bacillus due to restoration of the biological protective mechanisms.