Laffay N, Guérot C, Malergue M C, Tellier P, Gryman R, Valère P E, Tricot R
Arch Mal Coeur Vaiss. 1983 Jul;76(7):786-94.
Twenty patients with primary myocardial infarction (mean age 55 years +/- 6) were treated with intracoronary streptokinase in the acute phase. The mean interval between the onset of chest pain and treatment was 4 hours 30 minutes (extremes, 30 minutes and 6 hours). The total quantity of streptokinase required to obtain coronary revascularisation varied from patient to patient and with the technique used, but it was less than 350,000 units in all cases. The immediate results were favourable in 80 p. 100 of cases with respect to the coronary obstruction, in 50 p. 100 of cases with respect to relief of pain and in 35 p. 100 of cases with respect to ST elevation. It is not possible to confirm the efficacy of this therapy in left ventricular function from the results of this preliminary study. The authors observed, however, that the best results as assessed by 2D echocardiography, left ventricular angiography, and Thallium 201 myocardial scintigraphy were obtained in patients treated early (before the 3rd hour). They emphasise the need to check the level of antistreptokinase antibodies before starting treatment to assess the optimal total dosage for each individual patient, in order to obtain a local effect without disturbing the overall coagulation mechanism.
20例原发性心肌梗死患者（平均年龄55岁±6岁）在急性期接受了冠状动脉内链激酶治疗。胸痛发作至治疗的平均间隔时间为4小时30分钟（范围为30分钟至6小时）。实现冠状动脉再通所需的链激酶总量因患者和所采用的技术而异，但所有病例均少于350,000单位。就冠状动脉阻塞而言，80%的病例即刻结果良好；就疼痛缓解而言，50%的病例结果良好；就ST段抬高而言，35%的病例结果良好。从这项初步研究的结果尚无法证实该疗法对左心室功能的疗效。然而，作者观察到，通过二维超声心动图、左心室血管造影和铊201心肌闪烁显像评估，早期（第3小时之前）接受治疗的患者取得了最佳结果。他们强调，在开始治疗前需要检测抗链激酶抗体水平，以便评估每个患者的最佳总剂量，从而在不干扰整体凝血机制的情况下获得局部疗效。
