Evans R A, MacDonald D
Aust N Z J Med. 1983 Apr;13(2):175-6. doi: 10.1111/j.1445-5994.1983.tb02676.x.
Localised foot pain occurred in four patients with Paget's disease of bone or myositis ossificans who were treated with disodium etidronate (EHDP) in a dose of 10 to 20 mg/kg body weight/day for four to six months. There was localised tenderness and sometimes slight swelling at the painful areas. Bone x-rays were normal, but bone scans showed increased uptake of the isotope at these areas. The pain persisted for several weeks, causing considerable difficulty in walking. The symptoms were most likely due to diphosphonate-induced stress fractures. These cases emphasise the importance of administering EHDP in low dosage for short periods only.
4例患有骨佩吉特病或骨化性肌炎的患者接受依替膦酸二钠（EHDP）治疗，剂量为10至20mg/kg体重/天，持续4至6个月，出现了局部足部疼痛。疼痛部位有局部压痛，有时还有轻微肿胀。骨骼X线检查正常，但骨扫描显示这些部位的同位素摄取增加。疼痛持续了数周，导致行走困难。这些症状很可能是双膦酸盐诱导的应力性骨折所致。这些病例强调了仅短期使用低剂量EHDP的重要性。
