Huang T S, Tien H F, How S W, Chuang C Y, Sohail A B
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1983 May;16(2):84-91.
Two patients with "primary" plasma-cell dyscrasia, one with IgG kappa multiple myeloma and another with delta type light chain disease, are reported. Both of them presented extraosseous tumor mass on the forehead as an initial problem. They had moderate to severe anemia, accelerated ESR and multiple osteolytic lesions in the x-ray bone survey. They did not show prominent monoclonal spikes in serum electrophoregram and physiological immunoglobulins were not decreased. Repeated bone marrow aspirates on these two cases did not reveal definite plasmacytosis and pathological diagnosis was established by tumor biopsy. Immunopathological correlations were made, with an emphasis on rational analysis and interpretation of monoclonal proteins.
报告了两名患有“原发性”浆细胞发育异常的患者，一名患有IgG κ型多发性骨髓瘤，另一名患有δ型轻链病。他们两人均以额部骨外肿瘤肿块为首发问题。他们有中度至重度贫血、血沉加快，X线骨检查发现多处溶骨性病变。血清电泳图中未显示明显的单克隆峰，生理性免疫球蛋白未降低。对这两例患者反复进行骨髓穿刺未发现明确的浆细胞增多，通过肿瘤活检确立了病理诊断。进行了免疫病理学相关性分析，重点是对单克隆蛋白进行合理分析和解释。
