Kaneko T, Ozaki S, Ohkawa I, Yamatsu K
Nihon Yakurigaku Zasshi. 1983 Jun;81(6):481-92.
Analgesic and antipyretic effects of dl-2[3-(2'-chlorophenoxy)phenyl] propionic acid (CPP) were studied in mice, rats and guinea-pigs. CPP produced a dose dependent inhibition of acetic acid-induced writhing syndrome. Its ED50 values 1 and 3 hr after oral administration were 47 and 31 mg/kg, respectively. CPP had a potent analgesic effect on bradykinin-induced nociceptive response in rats, and its ED50 value was 15 mg/kg 2 hr after oral administration. The analgesic activity of CPP in these experiments was less potent than that of indomethacin, but it was approximately equivalent to ibuprofen and 10 to 20 times as potent as aspirin. CPP had no analgesic effect on both the tail pinch and hot plate tests in mice, while CPP potentiated the analgesic effect of codeine on these tests. CPP had no effect on the nociceptive response induced by intradermal injection of bradykinin and/or EDTA in guinea-pigs. On the other hand, when CPP was given orally in a dose range of 1.25 to 5 mg/kg, it produced an antipyretic effect on yeast-induced fever in rats. The antipyretic activity of CPP was equivalent to ibuprofen and 10 to 15 times as potent as aspirin.
研究了dl-2[3-(2'-氯苯氧基)苯基]丙酸（CPP）在小鼠、大鼠和豚鼠中的镇痛和解热作用。CPP对乙酸诱导的扭体综合征产生剂量依赖性抑制。口服给药后1小时和3小时其半数有效剂量（ED50）值分别为47和31毫克/千克。CPP对大鼠缓激肽诱导的伤害性反应有强效镇痛作用，口服给药后2小时其ED50值为15毫克/千克。在这些实验中，CPP的镇痛活性比吲哚美辛弱，但与布洛芬大致相当，且效力是阿司匹林的10至20倍。CPP对小鼠的夹尾和热板试验均无镇痛作用，而CPP可增强可待因在这些试验中的镇痛作用。CPP对豚鼠皮内注射缓激肽和/或乙二胺四乙酸（EDTA）诱导的伤害性反应无影响。另一方面，当以1.25至5毫克/千克的剂量口服CPP时，它对大鼠酵母诱导的发热产生解热作用。CPP的解热活性与布洛芬相当，且效力是阿司匹林的10至15倍。
