Genetic control of mouse antibody production to human thyroglobulin.

Genetic control of immune responses in mice against human thyroglobulin was studied using the enzyme-linked immunosorbent assay and passive haemagglutination test. Our results revealed that mice of H-2a, H-2d, H-2q, H-2k and H-2r haplotypes were high responders for antibody production to human thyroglobulin, while mice of H-2b and H-2s haplotypes were low responders. High responsiveness to human thyroglobulin was transmitted to F1 mice in a dominant fashion. Study of the genetic mapping of the immune responses to human thyroglobulin using various congenic mice showed that I-A subregion gene(s) control the immune response to human thyroglobulin.