Metabolic activation of 7,12-dimethylbenz[alpha]anthracene (DMBA) and 7-methylbenz[alpha]anthracene (7-MBA) by rat liver P-450 and sulfotransferase.
作者信息
Watabe T
出版信息
J Toxicol Sci. 1983 May;8(2):119-31. doi: 10.2131/jts.8.119.
PMID:6413699
Abstract
摘要
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Metabolic activation of 7,12-dimethylbenz[alpha]anthracene (DMBA) and 7-methylbenz[alpha]anthracene (7-MBA) by rat liver P-450 and sulfotransferase.
J Toxicol Sci. 1983 May;8(2):119-31. doi: 10.2131/jts.8.119.
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A 7-hydroxymethyl sulfate ester as an active metabolite of 7,12-dimethylbenz[alpha]anthracene.一种7-羟甲基硫酸酯作为7,12-二甲基苯并[a]蒽的活性代谢产物。
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Sulfate esters of hydroxymethyl-methyl-benz[a]anthracenes as active metabolites of 7,12-dimethylbenz[a]anthracene.羟甲基 - 甲基 - 苯并[a]蒽的硫酸酯作为7,12 - 二甲基苯并[a]蒽的活性代谢产物。
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The metabolism of 7,12-dimethylbenz[a]anthracene and 7-hydroxymethyl-12-methylbenz[a]anthracene by rat liver and adrenal homogenates and by rat adrenocortical cells.大鼠肝脏和肾上腺匀浆以及大鼠肾上腺皮质细胞对7,12-二甲基苯并[a]蒽和7-羟甲基-12-甲基苯并[a]蒽的代谢作用
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Selective interactions of cytochromes P-450 with the hydroxymethyl derivatives of 7,12-dimethylbenz[a]anthracene.细胞色素P-450与7,12-二甲基苯并[a]蒽羟甲基衍生物的选择性相互作用。
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The formation of dihydrodiols by the chemical or enzymic oxidation of 7-hydroxymethyl-12-methylbenz[alpha]anthracene and the possible role of hydroxymethyl dihydrodiols in the metabolic activation of 7,12-dimethylbenz[alpha]anthracene.7-羟甲基-12-甲基苯并[a]蒽经化学或酶促氧化形成二氢二醇以及羟甲基二氢二醇在7,12-二甲基苯并[a]蒽代谢活化中的可能作用。
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