Luderschmidt C, Plewig G
J Invest Dermatol. 1978 Apr;70(4):207-9. doi: 10.1111/1523-1747.ep12541329.
Circumscribed sebaceous gland hyperplasia (sebaceous hyperplasia) is a common benign facial tumor found in adults and aged. Seventeen biopsies of sebaceous hyperplasia from 10 patients, females and males aged 57-87 years were secured which were injected 45 min or up to 15 days prior with tritiated thymidine, and prepared for autoradiography. Specimens were evaluated by cell counts (labeling index, labeled total cells), and histoplanimetric techniques (sagittal section areas and circumference of sebaceous hyperplasia, of sebocytes, and of sebocyte nuclei). Controls were uninvolved sebaceous follicles from the same subjects, from an age-matched group, and from young male adults. In sebaceous hyperplasia the labeling index of basal cells is low with 5.7% +/- 2.3 vs uninvolved sebaceous follicles from the same subject (8.6% +/- 2.4) and the younger subjects with a value of 10.1% +/- 2.0). Labeled cells are retained in the acini much longer than in young adults (slowed down transit and turnover time). The glands of sebaceous hyperplasia are very large, their sebocytes are small, and many more basal cells are found per unit basement membrane length.
局限性皮脂腺增生（皮脂腺增生）是一种常见于成年人和老年人的面部良性肿瘤。从10名年龄在57至87岁的患者（男女均有）身上获取了17份皮脂腺增生活检样本，这些样本在注射氚标记胸腺嘧啶核苷前45分钟或长达15天，然后准备进行放射自显影。通过细胞计数（标记指数、标记总细胞数）和组织平面测量技术（皮脂腺增生、皮脂腺细胞和皮脂腺细胞核的矢状切面面积和周长）对样本进行评估。对照组为来自同一受试者、年龄匹配组和年轻男性成年人的未受累皮脂腺滤泡。在皮脂腺增生中，基底细胞的标记指数较低，为5.7%±2.3%，而同一受试者未受累的皮脂腺滤泡（8.6%±2.4%）以及年轻受试者的标记指数为10.1%±2.0%。标记细胞在腺泡中的保留时间比年轻人长得多（转运和周转时间减慢）。皮脂腺增生的腺体非常大，其皮脂腺细胞小，并且每单位基底膜长度发现更多的基底细胞。
