Chesters J K
J Inherit Metab Dis. 1983;6 Suppl 1:34-8. doi: 10.1007/BF01811321.
Deficiency of dietary Zn rapidly reduces both appetite and growth, the latter effect being apparently caused by a failure of cell replication. Diagnosis of presymptomatic Zn deficiency depends largely on estimation of plasma Zn concentration but is complicated by reductions of it during a range of stressful conditions. In the latter cases, the decrease in plasma Zn concentration does not appear to be associated with inadequate Zn intake. Only two genetic defects of Zn metabolism are known in animals. One is associated with lethally inadequate concentrations of Zn in the milk of mice, the other with the A46 trait in Friesian cattle. A46 is a recessively inherited defect of Zn absorption which is lethal in the absence of major Zn supplementation of the diet. The characteristics of the disease are very similar to those of acrodermatitis enteropathica in man.
膳食锌缺乏会迅速降低食欲和生长速度，后一种影响显然是由细胞复制失败引起的。症状前锌缺乏的诊断很大程度上取决于血浆锌浓度的测定，但在一系列应激条件下，血浆锌浓度的降低会使诊断变得复杂。在后一种情况下，血浆锌浓度的降低似乎与锌摄入不足无关。动物中已知的锌代谢遗传缺陷只有两种。一种与小鼠乳汁中锌浓度极低有关，另一种与弗里斯兰牛的A46性状有关。A46是一种隐性遗传的锌吸收缺陷，在不大量补充饮食锌的情况下是致命的。这种疾病的特征与人类的肠病性肢端皮炎非常相似。
