Conde E, Mazo E, Baro J, Lafarga M, Cuadrado M A, Recio M, Zubizarreta A
Acta Haematol. 1983;70(4):243-9. doi: 10.1159/000206735.
An ultrastructural study of the aspirated bone marrow of a patient with congenital dyserythropoietic anemia type I is presented. Both in transmission electron microscopy (TEM) and in scanning electron microscopy (SEM) ultrastructural abnormalities of the bone marrow erythroid precursors were seen. These abnormalities in TEM included uneven condensation of chromatin with spongy appearance and alterations of cellular division. The most striking among these alterations were: firstly, the intercellular bridges which were typified by the presence of chromatin and the absence of the midbody and contractile ring and, secondly, the anomalies of the nuclear membrane. Occasionally, autolytic areas within the cytoplasma and iron-laden mitochondria were to be seen. In the SEM the following features were notable: the length of the intercellular bridges, the absence of the central ridge in the midbody area, as well as the scanty number of cytoplasmic blebs on the surface of the bridges.
本文呈现了对一名I型先天性红细胞生成异常性贫血患者抽取的骨髓进行的超微结构研究。在透射电子显微镜（TEM）和扫描电子显微镜（SEM）下均观察到骨髓红系前体细胞的超微结构异常。TEM下的这些异常包括染色质凝聚不均呈海绵状外观以及细胞分裂改变。这些改变中最显著的是：其一，细胞间桥，其特征为存在染色质而无中间体和收缩环；其二，核膜异常。偶尔可见胞质内的自溶区域和含铁线粒体。在SEM下，以下特征值得注意：细胞间桥的长度、中间体区域无中央嵴以及桥表面胞质小泡数量稀少。
