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A new method of the measurement of the electrically neutral fluxes of cations through lipid bilayer membranes induced by Men+/nH+-exchangers.一种测量由Men+/nH+交换体诱导的阳离子通过脂质双分子层膜的电中性通量的新方法。
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Electrically silent anion transport through bilayer lipid membrane induced by tributyltin and triethyllead.三丁基锡和三乙基铅诱导的通过双层脂质膜的电沉默阴离子转运
J Membr Biol. 1990 Feb;113(2):109-13. doi: 10.1007/BF01872884.

一种测量由Men+/nH+交换体诱导的阳离子通过脂质双分子层膜的电中性通量的新方法。

A new method of the measurement of the electrically neutral fluxes of cations through lipid bilayer membranes induced by Men+/nH+-exchangers.

作者信息

Antonenko Y N, Yaguzhinsky L S

出版信息

FEBS Lett. 1983 Oct 31;163(1):42-5. doi: 10.1016/0014-5793(83)81158-2.

DOI:10.1016/0014-5793(83)81158-2
PMID:6414844
Abstract

Electrically neutral ionophores (nigericin, monencin) incorporated into a planar bilayer lipid membrane (BLM) bring about hydrogen ion gradient formation in the unstirred layers of BLM if a metal ion gradient on the membrane is prepared. Under these conditions a diffusion potential of a hydrogen ion is generated after addition of a protonophore. Cation selectivity of nigericin, monencin and A23187 has been studied by means of electrical potential measurements in the presence of a protonophore and Men+/nH+-exchangers mentioned above. The data on cation selectivity are in a good agreement with the well known results of the direct measurements of metal ion fluxes. This shows that the effect of generation of the potential on BLM in the presence of a protonophore and a Men+/nH+-exchanger can be used for the estimation of electrically neutral ion fluxes through BLM.

摘要

如果在平面双层脂质膜（BLM）上制备金属离子梯度，掺入该膜中的电中性离子载体（尼日利亚菌素、莫能菌素）会在BLM的未搅拌层中形成氢离子梯度。在这些条件下，加入质子载体后会产生氢离子扩散电位。通过在存在质子载体和上述Men⁺/nH⁺交换剂的情况下进行电位测量，研究了尼日利亚菌素、莫能菌素和A23187的阳离子选择性。阳离子选择性数据与金属离子通量直接测量的众所周知的结果高度一致。这表明，在存在质子载体和Men⁺/nH⁺交换剂的情况下，BLM上电位产生的效应可用于估算通过BLM的电中性离子通量。