短期给予睾酮对暴露于短日照的去势金黄仓鼠促卵泡激素（FSH）和促黄体生成素（LH）分泌的影响。

Effects of short-term treatment with testosterone on the secretion of FSH and LH in castrated golden hamsters exposed to short days.

作者信息

Urbanski H F, Simpson S M

出版信息

J Reprod Fertil. 1983 Nov;69(2):489-96. doi: 10.1530/jrf.0.0690489.

DOI:10.1530/jrf.0.0690489

Abstract

Castrated hamsters which were transferred from long (14L:10D) to short (9L:15D) days and received testosterone-filled capsules for 1 week after transfer failed to show a significant suppression in the plasma levels of FSH and LH after capsule removal. In contrast, gonadotrophin concentrations were suppressed in hamsters in which the long-day castration response had been blocked with exogenous testosterone. After castration on long days and exposure to 10 weeks of short days pituitary gland weight and gonadotrophin content, as well as plasma FSH titres, were higher in control animals than in those that had received testosterone implants for 7 weeks of short days. The results suggest that failure of castrated hamsters to respond to the suppressive effects of short days reflects castration-induced changes in hypothalamo-pituitary physiology rather than a neuroendocrine mechanism by which photoperiod modulates gonadotrophin secretion.

摘要

从长日照（14小时光照：10小时黑暗）转移至短日照（9小时光照：15小时黑暗）的去势仓鼠，在转移后接受含睾酮胶囊1周，去除胶囊后，其血浆促卵泡激素（FSH）和促黄体生成素（LH）水平未出现显著抑制。相比之下，在长日照去势反应已被外源性睾酮阻断的仓鼠中，促性腺激素浓度受到抑制。在长日照下进行去势并暴露于10周短日照后，对照动物的垂体重量、促性腺激素含量以及血浆FSH水平均高于在短日照下接受7周睾酮植入的动物。结果表明，去势仓鼠对短日照抑制作用无反应，反映了去势引起的下丘脑 - 垂体生理学变化，而非光周期调节促性腺激素分泌的神经内分泌机制。