Da Cunha M F, Meistrich M L, Ried H L, Gordon L A, Watchmaker G, Wyrobek A J
J Urol. 1983 Nov;130(5):927-30. doi: 10.1016/s0022-5347(17)51579-7.
The sperm production of 14 cancer patients who received doxorubicin was examined after cessation of therapy. Doxorubicin was used in several multiple-drug protocols for the treatment of various malignancies. Seven patients also received radiotherapy to different sites. Total cumulative doses of doxorubicin ranged from 145 to 625 mg./m.2. Sperm concentration, motility, morphology and the frequency of quinacrine-stained sperm with 2 fluorescent bodies (2F sperm) were measured 7 to 79 months after discontinuation of doxorubicin. Of the patients 6 remained azoospermic, 3 were oligospermic and 5 were normospermic. Sperm motility among the 8 patients with sperm ranged from 20 to 80 per cent. Morphology and 2F sperm distributions were not significantly different from controls. We conclude that, in contrast with the mechlorethamine, vincristine, procarbazine and prednisone protocol, active sperm production within relatively short recovery times is possible after treatment with protocols that include doxorubicin.
对14名接受阿霉素治疗的癌症患者在治疗停止后进行了精子生成情况检查。阿霉素被用于多种联合化疗方案中以治疗各种恶性肿瘤。7名患者还接受了不同部位的放射治疗。阿霉素的总累积剂量范围为145至625毫克/平方米。在停用阿霉素7至79个月后，对精子浓度、活力、形态以及经喹吖因染色后具有2个荧光小体的精子（2F精子）的频率进行了测量。这些患者中，6人无精子症，3人少精子症，5人精子正常。8名有精子的患者的精子活力在20%至80%之间。形态和2F精子分布与对照组无显著差异。我们得出结论，与氮芥、长春新碱、丙卡巴肼和泼尼松方案不同，在使用包含阿霉素的方案治疗后，在相对较短的恢复时间内有可能出现活跃的精子生成。
