Taguchi T
Gan No Rinsho. 1983 Aug;29(10):1058-62.
There are various patterns of recurrence of gastric and colorectal cancer after radical resection. In case of residual stomach recurrence, re-resection is sometimes feasible. Chemotherapy in such a case consists of combined chemotherapy by arterial infusion for induction of remission and administration of oral preparation and/or suppositories for maintenance. The results obtained from our clinic (recurrent gastric cancer: 101 cases, colorectal cancer: 27 cases) were shown as follows. The 50% survival period was 5 months. The twenty-one cases out of 101 cases in gastric cancer were survived more than one years, because they received the intensive chemotherapy such as arterial infusion chemotherapy and oral or rectal administration of FT. In case of recurrent colorectal cancer, 17 cases of 27 patients has multiple liver metastasis. The most patients of liver metastasis were treated with selective arterial infusion chemotherapy with 5-FU plus ACNU or MMC. And the efficacy of arterial infusion chemotherapy was remarkable. Our efforts must be made to continue any treatment as long as possible and change drugs as necessary. Also we must be made to keep general condition of the patients as good as possible using support therapy such as IVH, prevention of infection, immunotherapy, drainage so on.
胃癌和结直肠癌根治性切除术后存在多种复发模式。对于残胃复发，有时再次切除是可行的。在这种情况下，化疗包括通过动脉灌注进行联合化疗以诱导缓解，并给予口服制剂和/或栓剂进行维持治疗。我们诊所的结果（复发性胃癌：101例，结直肠癌：27例）如下所示。50%生存期为5个月。胃癌101例中有21例存活超过1年，因为他们接受了强化化疗，如动脉灌注化疗以及口服或直肠给予FT。对于复发性结直肠癌，27例患者中有17例有多发肝转移。大多数肝转移患者接受了5-氟尿嘧啶联合阿糖胞苷或丝裂霉素的选择性动脉灌注化疗。并且动脉灌注化疗的疗效显著。我们必须努力尽可能长时间地持续任何治疗，并根据需要更换药物。此外，我们必须通过静脉输液、预防感染、免疫治疗、引流等支持治疗，尽可能保持患者的一般状况良好。
