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类固醇诱导的中枢神经系统肿瘤镓摄取抑制:简要通讯

Steroid-induced suppression of gallium uptake in tumors of the central nervous system: concise communication.

作者信息

Waxman A D, Beldon J R, Richli W, Tanasescu D E, Siemsen J K

出版信息

J Nucl Med. 1978 May;19(5):480-2.

PMID:641569
Abstract

The effect of steroids given in greater than replacement doses on the gallium and technetium glucoheptonate brain scan is evaluated by comparing the relative sensitivity of both radiopharmaceuticals in patients both on and off steroids. The study shows a significant steroid effect on the sensitivity of 95% to 64% following steroids. Steroids did not significantly alter the sensitivity of the technetium glucoheptonate study. The superiority of the TcGH brain scan over the gallium citrate brain scan in the steroid population suggests a difference in the uptake mechanism for the two radiopharmaceuticals.

摘要

通过比较接受和未接受类固醇治疗的患者中两种放射性药物的相对敏感性,评估给予大于替代剂量的类固醇对镓和葡庚糖酸锝脑扫描的影响。研究表明,类固醇对敏感性有显著影响,使用类固醇后敏感性从95%降至64%。类固醇并未显著改变葡庚糖酸锝研究的敏感性。在使用类固醇的人群中,TcGH脑扫描优于枸橼酸镓脑扫描,这表明两种放射性药物的摄取机制存在差异。

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Failure of Gallium-68 citrate to detect large, enhancing, intracerebral central nervous system tuberculomas: A cautionary tale.枸橼酸镓-68未能检测出大型、强化的脑内中枢神经系统结核瘤:一则警示故事。
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Drug interactions with radiopharmaceuticals.药物与放射性药物的相互作用。
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