Lowy M T, Yim G K
Psychopharmacology (Berl). 1983;81(1):28-32. doi: 10.1007/BF00439269.
The proposed mu and kappa opiate receptor agonists morphine and ketocyclazocine, as well as meperidine, were compared for their ability to stimulate feeding and drinking by male rats and hamsters that were not deprived of food or water. Morphine (8.0 mg/kg) and ketocyclazocine (0.5-4.0 mg/kg), but not meperidine (0.5-64.0 mg/kg), increased 3-h food intake by rats. By 6 h the hyperphagic responses were less pronounced. However, 6-h water intake was increased by all three agonists. In contrast to rats, hamsters failed to increased food or water intake over an 8-h period following morphine (6.25-800 mg/kg), ketocyclazocine (0.25-16.0 mg/kg), or meperidine (1.0-128 mg/kg) administration. Thus, kappa or mu opiate receptors may mediate the observed hyperphagic effect of opiate agonists on rat food intake. In addition, these results are consistent with our earlier suggestion that hamsters lack an opiate-sensitive feeding system.
将拟用的μ和κ阿片受体激动剂吗啡、酮环唑新以及哌替啶，针对未剥夺食物或水的雄性大鼠和仓鼠刺激进食和饮水的能力进行了比较。吗啡（8.0毫克/千克）和酮环唑新（0.5 - 4.0毫克/千克）可增加大鼠3小时的食物摄入量，但哌替啶（0.5 - 64.0毫克/千克）则无此作用。到6小时时，食欲亢进反应就不那么明显了。然而，所有这三种激动剂都增加了大鼠6小时的饮水量。与大鼠不同，给予吗啡（6.25 - 800毫克/千克）、酮环唑新（0.25 - 16.0毫克/千克）或哌替啶（1.0 - 128毫克/千克）后，仓鼠在8小时内未能增加食物或水的摄入量。因此，κ或μ阿片受体可能介导了阿片激动剂对大鼠食物摄入量所观察到的食欲亢进作用。此外，这些结果与我们之前提出的仓鼠缺乏阿片敏感进食系统的观点一致。
