Kavaliers M, Hirst M
Pharmacol Biochem Behav. 1986 Sep;25(3):543-8. doi: 10.1016/0091-3057(86)90138-3.
The feeding behavior of the deer mouse, Peromyscus maniculatus, includes food hoarding as well as ingestion. Administration of the prototypical mu opiate agonist, morphine sulfate, 1-20 mg/kg, produced over three hours a significant dose-dependent stimulation of hoarding by free feeding deer mice. The specific kappa opiate agonist, U-50,488H, 0.10-10 mg/kg, markedly increased ingestion without having any augmentatory effects on hoarding. The mixed mu and kappa opiate agonist, ketocyclazocine hydrochloride, 1-10 mg/kg, as well as various combinations of morphine sulfate and U-50,488H, augmented both hoarding and ingestion. Food restriction for 24 hr caused a significant, naloxone (1.0 mg/kg) reversible, increase in food intake. Food deprivation also modified the hoarding and ingestion responses of the deer mice to the mu and kappa opiate agonists, reducing the relative amounts of food that were hoarded. These results indicate that mu and kappa opioid systems are differentially involved in the mediation of various aspects of feeding. This also suggests that environmental factors, such as food restriction, can modify the relative roles of mu and kappa opioid systems in the expression of feeding behavior.
鹿鼠（白足鼠）的摄食行为包括食物贮藏和摄取。给自由取食的鹿鼠注射1-20毫克/千克的典型μ阿片受体激动剂硫酸吗啡，在三个多小时内产生了显著的剂量依赖性贮藏刺激。注射0.10-10毫克/千克的特异性κ阿片受体激动剂U-50,488H，显著增加了摄取量，而对贮藏没有任何增强作用。注射1-10毫克/千克的μ和κ阿片受体混合激动剂盐酸酮环唑辛，以及硫酸吗啡和U-50,488H的各种组合，增强了贮藏和摄取。禁食24小时导致食物摄入量显著增加，且可被纳洛酮（1.0毫克/千克）逆转。食物剥夺也改变了鹿鼠对μ和κ阿片受体激动剂的贮藏和摄取反应，减少了贮藏的食物相对量。这些结果表明，μ和κ阿片系统在摄食行为的各个方面的调节中发挥不同作用。这也表明，环境因素，如食物限制，可以改变μ和κ阿片系统在摄食行为表达中的相对作用。
