颅脑放疗对生长激素对精氨酸和胰岛素输注反应的不同影响。

Differential effects of cranial radiation on growth hormone response to arginine and insulin infusion.

作者信息

Dickinson W P, Berry D H, Dickinson L, Irvin M, Schedewie H, Fiser R H, Elders M J

出版信息

J Pediatr. 1978 May;92(5):754-7. doi: 10.1016/s0022-3476(78)80143-7.

Abstract

The growth hormone responses to arginine infusion and to insulin-induced hypoglycemia were studied in 13 patients with neoplastic disease after treatment with radiation and chemotherapy. Patients who received intensive cranial radiation (greater than 2,400 rads) had no response to either arginine or insulin; those who received moderate cranial radiation (greater than or equal to 2,400 rads) had GH response to arginine but not to insulin; patients receiving no cranial radiation responded to both arginine and insulin. These data support the hypothesis that GH secretion in response to arginine infusion has a different mechanism in contrast to the response to insulin-induced hypoglycemia and that the latter is more vulnerable to cranial radiation.

摘要

对13例接受放疗和化疗的肿瘤患者，研究了其生长激素对精氨酸输注及胰岛素诱发低血糖的反应。接受大剂量头颅放疗（大于2400拉德）的患者对精氨酸或胰岛素均无反应；接受中等剂量头颅放疗（大于或等于2400拉德）的患者对精氨酸有生长激素反应，但对胰岛素无反应；未接受头颅放疗的患者对精氨酸和胰岛素均有反应。这些数据支持了这样的假说，即与胰岛素诱发低血糖的反应相比，精氨酸输注后生长激素分泌的机制不同，且后者对头颅放疗更敏感。