Grenby T H, Colley J
Arch Oral Biol. 1983;28(8):745-58. doi: 10.1016/0003-9969(83)90111-5.
Xylitol at 10 and 20 per cent disturbed gastro-intestinal function but was tolerated better than sorbitol or mannitol. Toleration improved when dietary polyol levels were increased gradually to a maximum of 20 per cent. Twenty per cent of xylitol in the diet replacing that amount of sucrose reduced the level of caries, but 20 per cent of wheat starch was equally effective. Ten per cent of xylitol in place of sucrose produced as much caries as the basic cariogenic diet, but xylitol at a level of 2 per cent was associated with an increase in caries. There was no confirmation of an active caries-reversing effect of xylitol when xylitol-containing diets were alternated with the basic high-sucrose cariogenic ration.
10%和20%的木糖醇会干扰胃肠功能，但比山梨醇或甘露醇的耐受性更好。当膳食多元醇水平逐渐增加至最高20%时，耐受性有所改善。用饮食中20%的木糖醇替代等量蔗糖可降低龋齿水平，但20%的小麦淀粉同样有效。用10%的木糖醇替代蔗糖产生的龋齿量与基本致龋饮食相同，但2%的木糖醇水平会导致龋齿增加。当含木糖醇的饮食与基本的高蔗糖致龋饮食交替时，未证实木糖醇有积极的防龋作用。
