Havenaar R
J Dent Res. 1984 Feb;63(2):120-3. doi: 10.1177/00220345840630020401.
Previous rat caries experiments in our laboratory demonstrated an anti-cariogenic and most probably a remineralizing effect of xylitol. The purpose of the present study was to compare the caries-inhibiting property of xylitol and fluoride in drinking water. The study consisted of two experiments with Osborne-Mendel rats, superinfected with S. mutans. In the first experiment, the rats were fed ad libitum a cariogenic diet containing 20% sucrose and 5% glucose (diet SSP 20/5) and tap water containing 0%, 2%, or 4% xylitol. An additional control group was fed diet SSP 20/5 supplemented with 5% xylitol. In the second experiment, the rats were also fed diet SSP 20/5, but received tap water, demineralized water (both containing less than 0.1 ppm F-), or tap water containing 10 and 40 ppm fluoride. Some animals in the 4% xylitol drinking water group showed a mild osmotic diarrhea for the first four days and a retarded increase in body weight of limited duration. S. mutans colonized to a similar level in all groups of both experiments. Fluoride as well as xylitol in the drinking water reduced the fissure caries scores significantly. However, 10 and 40 ppm fluoride had a more pronounced inhibiting effect on the caries experience than did 4% xylitol in the drinking water or 5% xylitol in the diet.
我们实验室之前的大鼠龋齿实验证明了木糖醇具有防龋作用，并且很可能具有再矿化作用。本研究的目的是比较饮用水中木糖醇和氟化物的防龋特性。该研究由两项针对感染变形链球菌的奥斯本-孟德尔大鼠的实验组成。在第一个实验中，大鼠随意进食含20%蔗糖和5%葡萄糖的致龋饮食（SSP 20/5饮食）以及含0%、2%或4%木糖醇的自来水。另外一个对照组喂食添加了5%木糖醇的SSP 20/5饮食。在第二个实验中，大鼠同样喂食SSP 20/5饮食，但饮用自来水、去离子水（两者氟含量均低于0.1 ppm）或含10 ppm和40 ppm氟化物的自来水。4%木糖醇饮用水组的一些动物在最初四天出现轻度渗透性腹泻，体重增加暂时减缓。在两个实验的所有组中，变形链球菌的定殖水平相似。饮用水中的氟化物和木糖醇均显著降低了窝沟龋评分。然而，与饮用水中4%的木糖醇或饮食中5%的木糖醇相比，10 ppm和40 ppm的氟化物对龋齿发生率的抑制作用更为显著。
