Pelleymounter M A, Lorden J F
Behav Neurosci. 1983 Oct;97(5):810-21. doi: 10.1037//0735-7044.97.5.810.
Reductions in central catecholamines produced by intraventricular injections of 6-hydroxydopamine (6-OHDA) cause weight loss and decreased plasma glucose in diabetes (db/db) mice. The effects of this treatment were examined in short-term (64-day) and long-term (120-day) survival groups. Diabetes mice treated with 6-OHDA decreased food intake, lost weight, and maintained a lower weight than vehicle-treated controls until vehicle-treated animals began to enter the terminal stages of the syndrome, indicated by a loss of body weight. Diabetes mice given 6-OHDA lost weight despite reduced body temperatures and activity levels. Blood glucose levels were always lower in 6-OHDA than in ad lib fed vehicle-treated db/db mice. The 6-OHDA treatment also improved pancreatic islet granulation. Pair feeding vehicle-treated with 6-OHDA-treated db/db mice did not halt weight gain in the vehicle-treated group. However, measurement of carcass fat indicated similar losses in db/db-6-OHDA mice and vehicle-treated mice when the vehicle group was pair-fed with lean controls. Treatment with 6-OHDA produced long-term improvement in the diabetes syndrome, but the decreased body weight of the 6-OHDA-treated diabetes mice could not be completely accounted for by changes in food intake or measured indices of energy expenditure.
脑室内注射6-羟基多巴胺（6-OHDA）导致中枢儿茶酚胺减少，会引起糖尿病（db/db）小鼠体重减轻和血糖降低。在短期（64天）和长期（120天）存活组中研究了这种治疗的效果。用6-OHDA治疗的糖尿病小鼠食物摄入量减少、体重减轻，并且在载体处理的动物开始进入综合征末期（以体重减轻为指标）之前，其体重一直低于载体处理的对照组。给予6-OHDA的糖尿病小鼠尽管体温和活动水平降低，但体重仍减轻。6-OHDA处理组的血糖水平始终低于随意进食的载体处理的db/db小鼠。6-OHDA治疗还改善了胰岛颗粒化。将载体处理的db/db小鼠与6-OHDA处理的db/db小鼠配对饲养，并不能阻止载体处理组的体重增加。然而，当载体组与瘦对照组配对饲养时，对胴体脂肪的测量表明，db/db-6-OHDA小鼠和载体处理小鼠的脂肪损失相似。6-OHDA治疗使糖尿病综合征得到了长期改善，但6-OHDA治疗的糖尿病小鼠体重下降不能完全用食物摄入量的变化或能量消耗的测量指标来解释。
