Gottuso M A, Oski B F, Oski F A
J Pediatr. 1978 May;92(5):810-2. doi: 10.1016/s0022-3476(78)80163-2.
Red cell free erythrocyte porphyrin determinations were performed on cord blood specimens from 236 term infants and on capillary blood specimens from 63 preterm infants weighing less than 1,500 gm, during the first week of life. These results were contrasted with those obtained from 398 normal infants and children ages 1 to 6 years. The mean FEP value for the infants was significantly higher than that observed in the normal control subjects. In 10.5% of the term infants and 15.9% of the preterm infants, values in excess of 120 microgram/dl RBCs, the highest value recorded in the normal subjects, were observed. Elevations in FEP values were not related to either blood lead concentration or hematocrit levels in the infants. Infants with elevated FEP values were found to have lower serum iron and transferrin saturation values than did infants with low FEP values. These findings suggest that elevations in cord blood FEP values may indicate a state of relative iron deficiency present at birth.
在出生后第一周，对236名足月儿的脐血标本以及63名体重小于1500克的早产儿的毛细血管血标本进行了无细胞红细胞卟啉测定。将这些结果与398名1至6岁正常婴幼儿的结果进行了对比。婴幼儿的平均FEP值显著高于正常对照对象。在10.5%的足月儿和15.9%的早产儿中，观察到超过120微克/分升红细胞（正常对象记录的最高值）的值。婴幼儿FEP值的升高与血铅浓度或血细胞比容水平均无关。发现FEP值升高的婴幼儿血清铁和转铁蛋白饱和度值低于FEP值低的婴幼儿。这些发现表明，脐血FEP值升高可能表明出生时存在相对缺铁状态。
