蛋白质缺乏大鼠的心肌变力反应与肾上腺素能受体
Myocardial inotropic responses and adrenoceptors in protein-deficient rats.
作者信息
Benfey B G, Varma D R, Yue T L
出版信息
Br J Pharmacol. 1983 Nov;80(3):527-31. doi: 10.1111/j.1476-5381.1983.tb10725.x.
Abstract
Inotropic effects of isoprenaline, phenylephrine and calcium were studied in left atria of 5 weeks old rats fed a low (5%) or a normal (21%) protein diet for 3 weeks. Rats maintained on a low (5%) protein diet consume about half the amount of food eaten by the same rats maintained on a normal (21%) protein diet and thus suffer from protein-calorie malnutrition (PCM). Body weight did not increase in PCM, but heart weight adjusted to body weight was slightly increased compared to normal rats. Atrial resting tension and peak developed tension in response to isoprenaline, phenylephrine or calcium were not diminished by PCM. The number of alpha and beta-adrenoceptors and the receptor affinity in ventricular membranes were not reduced by PCM.
摘要
在喂食低蛋白（5%）或正常蛋白（21%）饮食3周的5周龄大鼠的左心房中，研究了异丙肾上腺素、去氧肾上腺素和钙的变力作用。维持低蛋白（5%）饮食的大鼠所摄入的食物量约为维持正常蛋白（21%）饮食的同一只大鼠所摄入食物量的一半，因此患有蛋白质-热量营养不良（PCM）。PCM大鼠的体重没有增加，但与正常大鼠相比，根据体重调整后的心脏重量略有增加。PCM并未降低心房静息张力以及对异丙肾上腺素、去氧肾上腺素或钙的反应中产生的峰值张力。心室膜中α和β肾上腺素能受体的数量以及受体亲和力并未因PCM而降低。
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