Eskay R L, Long R T, Palkovits M
Brain Res. 1983 Oct 24;277(1):159-62. doi: 10.1016/0006-8993(83)90919-8.
The distribution of thyrotropin releasing hormone (TRH) in individual nuclei of the rat brainstem was examined by radioimmunoassay. TRH was detectable in 36 of 40 brainstem nuclei investigated and the localization of TRH in the brainstem was unlike other known brainstem neuropeptides. By far the highest concentration of TRH in the brainstem (1.2 ng/mg protein) is present in the nucleus of the solitary tract. The concentration of TRH was relatively high in the motor nuclei of the IIIrd, Vth, VIIth, Xth and XIIth cranial nerves, and less high in the area postrema, nucleus gracilis, locus coeruleus, lateral reticular nucleus (A1-catecholamine cell group), dorsal raphe and central gray matter. Cerebellum and pontine nuclei contained very low levels (less than 0.03 ng/mg protein) of TRH.
采用放射免疫分析法检测了促甲状腺激素释放激素（TRH）在大鼠脑干各个核团中的分布。在所研究的40个脑干核团中，有36个可检测到TRH，且TRH在脑干中的定位与其他已知的脑干神经肽不同。目前，脑干中TRH浓度最高（1.2 ng/mg蛋白质）的是孤束核。在第Ⅲ、Ⅴ、Ⅶ、Ⅹ和Ⅻ对脑神经的运动核中，TRH浓度相对较高，而在最后区、薄束核、蓝斑、外侧网状核（A1-儿茶酚胺细胞群）、中缝背核和中央灰质中的浓度则较低。小脑和脑桥核中的TRH水平非常低（低于0.03 ng/mg蛋白质）。
