Devery R A, Collins P B, Johnson A H, Watson R G
Comp Biochem Physiol B. 1983;76(3):549-53. doi: 10.1016/0305-0491(83)90291-2.
Lysosomes are known to be implicated in many disease states in both humans and animals. In order to assess the possible role of lysosomes in the aetiology of human gastric ulceration, lysosomal enzyme levels and some of their properties were determined in human gastric antrum and in three discrete porcine gastric regions. Of the four regions investigated, the strongest similarity emerged between the enzymes of the porcine pyloric gland area and those of the human antrum. These data suggest that the pyloric gland is an appropriate model tissue for a comparative in vitro study of lysosomal involvement in human gastric ulceration.
众所周知，溶酶体与人类和动物的许多疾病状态有关。为了评估溶酶体在人类胃溃疡病因学中的可能作用，我们测定了人类胃窦以及猪胃三个不同区域的溶酶体酶水平及其一些特性。在所研究的四个区域中，猪幽门腺区域的酶与人类胃窦的酶之间表现出最强的相似性。这些数据表明，幽门腺是用于体外比较研究溶酶体与人类胃溃疡关系的合适模型组织。
