Kurozumi T, Tanaka K, Kido M, Shoyama Y
Exp Mol Pathol. 1983 Dec;39(3):377-86. doi: 10.1016/0014-4800(83)90066-7.
Monocrotaline, an alkaloid obtained from Crotalaria spectabilis, provides an experimental model for studies of mesangiolysis as seen in Habu venom poisoning and hemolytic-uremic syndrome. Renal lesions induced in rats by a single intraperitoneal administration of monocrotaline were examined by light and electron microscopy. Two weeks after the injection glomerular capillaries showed focal endothelial cell detachment and adhesion of platelets to the basal lamina. At 3 weeks there was no endothelial denudation but the mesangium was severely edematous. Mesangiolysis occurred at 4 weeks, accompanied by dilatation or obliteration of capillaries and necrosis and hemorrhage in the mesangium. Insudation of plasma constituents facilitated by the endothelial injury appeared important in the pathogenesis of mesangiolysis. Fusion of capillaries seemed to lead to capillary aneurysmata and necrosis of the mesangium. These glomerular lesions induced by monocrotaline were similar to those of Habu venom poisoning or hemolytic-uremic syndrome.
野百合碱是从美丽猪屎豆中提取的一种生物碱，它为研究在哈布蛇毒中毒和溶血尿毒综合征中所见的肾小球系膜溶解提供了一个实验模型。通过光镜和电镜检查了单次腹腔注射野百合碱诱导的大鼠肾脏病变。注射后两周，肾小球毛细血管显示局灶性内皮细胞脱离以及血小板黏附于基膜。3周时无内皮剥脱，但系膜严重水肿。4周时发生肾小球系膜溶解，伴有毛细血管扩张或闭塞以及系膜坏死和出血。内皮损伤促进血浆成分渗出似乎在肾小球系膜溶解的发病机制中起重要作用。毛细血管融合似乎导致毛细血管瘤形成和系膜坏死。野百合碱诱导的这些肾小球病变与哈布蛇毒中毒或溶血尿毒综合征的病变相似。
