Chau P Y, Ling J, Ng W S
J Antimicrob Chemother. 1983 Oct;12(4):337-45. doi: 10.1093/jac/12.4.337.
The in-vitro activities of cefoperazone, cefotaxime, ceftriaxone, latamoxef (moxalactam), ceftazidime and N-formimidoyl-thienamycin (N-f-thienamycin) were compared against clinical isolates of Pseudomonas aeruginosa that were resistant to carbenicillin and gentamicin, or against those which were susceptible. N-f-thienamycin and ceftazidime were more active than cefotaxime, ceftriaxone and latamoxef only against carbenicillin-susceptible isolates: isolates resistant to carbenicillin exhibited markedly increased resistance to cefoperazone, but not to N-f-thienamycin or ceftazidime. A partial cross-resistance was observed between carbenicillin and cefoperazone. This was due to the presence in these Pseudomonas isolates of a plasmid-mediated beta-lactamase which was active against carbenicillin and cefoperazone but not against cefotaxime, ceftriazone and latamoxef.
比较了头孢哌酮、头孢噻肟、头孢曲松、拉氧头孢（羟羧氧酰胺菌素）、头孢他啶和N-甲酰亚胺基硫霉素（N-f-硫霉素）对耐羧苄西林和庆大霉素的铜绿假单胞菌临床分离株或敏感分离株的体外活性。仅对羧苄西林敏感的分离株，N-f-硫霉素和头孢他啶比头孢噻肟、头孢曲松和拉氧头孢更具活性：耐羧苄西林的分离株对头孢哌酮的耐药性显著增加，但对N-f-硫霉素或头孢他啶无此现象。在羧苄西林和头孢哌酮之间观察到部分交叉耐药性。这是由于这些假单胞菌分离株中存在一种质粒介导的β-内酰胺酶，该酶对羧苄西林和头孢哌酮有活性，但对头孢噻肟、头孢曲松和拉氧头孢无活性。
