花生四烯酸对兔后肢血管床血管收缩反应的影响。

Influence of arachidonic acid on vasoconstrictor responses in the rabbit hindquarters vascular bed.

作者信息

Lippton H L, Gottlieb A L, Landry A Z, Kadowitz P J

出版信息

Prostaglandins Leukot Med. 1983 Oct;12(2):125-36. doi: 10.1016/0262-1746(83)90076-8.

Abstract

The effects of infusion of arachidonic acid (AA) on responses to pressor hormones and sympathetic nerve stimulation were investigated in the hindquarters vascular bed of the rabbit. During infusion of AA, vasoconstrictor responses to norepinephrine, nerve stimulation and angiotensin II were reduced to a similar extent. In addition, AA decreased hindquarters perfusion pressure and systemic arterial pressure. Following the administration of indomethacin, vasoconstrictor responses as well as perfusion pressure and aortic pressure remained unchanged during infusion of AA. The present data show that AA possesses the ability to modulate responses to nerve stimulation and pressor hormones. In addition, AA dilates the hindquarters vascular bed and produces a systemic depressor response. The present data suggest that cyclooxygenase products possessing vasodilator activity may mediate the effects of AA on the sympathetic nervous system and responses to pressor hormones in the rabbit hindquarters vascular bed.

摘要

在兔后肢血管床中研究了注入花生四烯酸（AA）对升压激素反应和交感神经刺激的影响。在注入AA期间，对去甲肾上腺素、神经刺激和血管紧张素II的血管收缩反应降低到相似程度。此外，AA降低了后肢灌注压和全身动脉压。给予吲哚美辛后，在注入AA期间血管收缩反应以及灌注压和主动脉压保持不变。目前的数据表明，AA具有调节对神经刺激和升压激素反应的能力。此外，AA使后肢血管床扩张并产生全身降压反应。目前的数据表明，具有血管舒张活性的环氧化酶产物可能介导AA对兔后肢血管床交感神经系统和升压激素反应的影响。