使用分子连接性研究麻醉醚的构效关系。
Structure--activity relationships of anesthetic ethers using molecular connectivity.
作者信息
Di Paolo T
出版信息
J Pharm Sci. 1978 Apr;67(4):564-6. doi: 10.1002/jps.2600670436.
PMID:641774
Abstract
The structure--activity relationships in the anesthetic and toxic actions of 28 aliphatic ethers were simple functions of molecular connectivity indexes. These quantitative relationships are discussed briefly in the light of theories of the mechanism of action of general anesthetics.
摘要
28种脂肪族醚的麻醉和毒性作用中的构效关系是分子连接性指数的简单函数。根据全身麻醉作用机制的理论，简要讨论了这些定量关系。
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