奎尼丁吸收与崩解及溶解速率的相关性。

Correlation of quinidine absorption with disintegration and dissolution rates.

作者信息

Strum J D, Ebersole J W, Jaffe J M, Colaizzi J L, Poust R I

出版信息

J Pharm Sci. 1978 Apr;67(4):568-9. doi: 10.1002/jps.2600670438.

Abstract

The dissolution profiles of four commercial quinidine sulfate tablets were determined using the USP rotating-basked dissolution apparatus. Substantial differences in dissolution half-times were noted and compared to previously reported disintegration times, absorption rate constants, and times of appearance of peak serum concentrations. Rank-order correlations were observed among all combinations of in vivo and in vitro parameters, indicating that the absorption rates of these tablets are controlled by both disintegration and dissolution.

摘要

使用美国药典转篮法溶出装置测定了四种市售硫酸奎尼丁片剂的溶出曲线。观察到溶出半衰期存在显著差异，并与先前报道的崩解时间、吸收速率常数和血药浓度峰值出现时间进行了比较。在体内和体外参数的所有组合之间均观察到等级相关，表明这些片剂的吸收速率受崩解和溶出两者控制。