Colburn W A, Gibaldi M
J Pharm Sci. 1978 Apr;67(4):574-5. doi: 10.1002/jps.2600670441.
MULTDOS, a computer method to curve fit data obtained on multiple dosing, was used with either the 1969 or 1974 version of the NONLIN program to compare the pharmacokinetic parameters of ethosuximide during repetitive administration of single or divided daily doses. Elimination rate constants, excretion rate constants, and apparent volumes of distribution were similar between the two dosing regimens and essentially identical between the two nonlinear regression programs.
MULTDOS是一种用于对多次给药所获数据进行曲线拟合的计算机方法，它与1969版或1974版的NONLIN程序一起，用于比较在单次或每日分剂量重复给药期间乙琥胺的药代动力学参数。两种给药方案的消除速率常数、排泄速率常数和表观分布容积相似，并且在两个非线性回归程序之间基本相同。
