α-二氟甲基鸟氨酸诱导的9L肿瘤细胞多胺耗竭改变了药物诱导的DNA交联形成。
alpha-Difluoromethylornithine-induced polyamine depletion of 9L tumor cells modifies drug-induced DNA cross-link formation.
作者信息
Tofilon P J, Deen D F, Marton L J
出版信息
Science. 1983 Dec 9;222(4628):1132-5. doi: 10.1126/science.6417790.
PMID:6417790
Abstract
Depletion of intracellular levels of polyamines, which are believed to have a role in the intranuclear stabilization of DNA, alters the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and cis-diamminedichloroplatinum II in 9L rat brain tumor cells. Alkaline elution techniques were used to show that polyamine depletion alters the number of DNA cross-links formed by these cytotoxic agents.
摘要
多胺在细胞核内对DNA具有稳定作用，细胞内多胺水平的耗竭会改变1,3 - 双(2 - 氯乙基)-1 - 亚硝基脲和顺 - 二氯二氨铂(II)对9L大鼠脑肿瘤细胞的细胞毒性。采用碱性洗脱技术表明，多胺耗竭会改变这些细胞毒性药物形成的DNA交联数量。
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