Blanco-Garcia M, Job J C, Chaussain J L, Canlorbe P
Arch Fr Pediatr. 1983 Oct;40(8):637-42.
Thirty-four boys with true precocious puberty were observed: In 28, precocious puberty was related to intracranial causes (17 tumors, 11 other lesions), in 3, it was due to extrapituitary gonadotropin-secreting tumors and in 3 it appeared idiopathic. The clinical development of sex characteristics was slower than the advance of bone age and the increase in hormone levels (plasma testosterone and pituitary gonadotropin reserve as measured by the LH-RH test). Cyproterone treatment seemed more effective than medroxyprogesterone, with respect to both sexual development and evolution of the bone age/height age ratio or the predictable adult height.
观察了34例真性性早熟男孩：其中28例性早熟与颅内病因有关（17例肿瘤，11例其他病变），3例是由于垂体外分泌促性腺激素的肿瘤引起，3例表现为特发性。性征的临床发育比骨龄进展和激素水平升高（血浆睾酮以及通过LH-RH试验测定的垂体促性腺激素储备）要慢。就性发育以及骨龄/身高年龄比或可预测的成人身高的演变而言，环丙孕酮治疗似乎比甲羟孕酮更有效。
