酮洛芬赖氨酸缓释制剂在人体中的药代动力学
Pharmacokinetics of a slow-release preparation of ketoprofen lysine in man.
作者信息
Borsa M, Tonon G C, Ronchi C, Zanolo G, Canali S
出版信息
Arzneimittelforschung. 1983;33(10):1497-500.
The lysine salt of 2-(3-benzoylphenyl)propionic acid (ketoprofen lysine) was administered at the dose of 160 mg either in two conventional capsules (Artrosilene) or in one slow-release capsule in a randomized sequence to 8 volunteers. Serum and urine concentrations of ketoprofen were determined by HPLC. The slow-release preparation had a bioavailability greater than 90% as compared with the conventional capsule and produced lower and longer lasting ketoprofen serum levels. These results suggest that two daily administrations of the new formulation should be suitable for therapeutic use.
2-(3-苯甲酰基苯基)丙酸赖氨酸盐（酮洛芬赖氨酸盐）以160毫克的剂量，采用随机顺序，给8名志愿者分别服用两个常规胶囊（Artrosilene）或一个缓释胶囊。通过高效液相色谱法测定血清和尿液中酮洛芬的浓度。与常规胶囊相比，缓释制剂的生物利用度大于90%，且产生的酮洛芬血清水平更低、持续时间更长。这些结果表明，每日服用两次这种新制剂应适用于治疗用途。
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