Akhtar F B, Marshall G R, Nieschlag E
Int J Androl. 1983 Oct;6(5):461-8. doi: 10.1111/j.1365-2605.1983.tb00560.x.
Continuous administration of LHRH agonists in high doses disrupts pituitary and testicular function, thus providing an approach to male fertility control. However, testosterone supplementation is required to prevent the side effects associated with low androgen concentrations resulting from chronic LHRH agonist treatment. Three adult male rhesus monkeys were treated with the LHRH agonist, Buserelin, using osmotic minipumps implanted subcutaneously. Testosterone was administered simultaneously via Silastic capsules. This combined treatment led to a marked decrease in testicular volume, and all animals were oligospermic within 8-15 weeks of treatment. Azoospermia was, however, not achieved even after 22 weeks of treatment although in a previous study in which the LHRH agonist had been administered alone, azoospermia had been achieved after 8-10 weeks. It is concluded that in this primate species testosterone supplementation attenuates the suppressive effects of LHRH agonist infusion on spermatogenesis.
高剂量持续给予促黄体生成素释放激素（LHRH）激动剂会破坏垂体和睾丸功能，从而提供一种控制男性生育能力的方法。然而，需要补充睾酮以预防因长期使用LHRH激动剂治疗导致雄激素浓度降低相关的副作用。使用皮下植入的渗透微型泵，对三只成年雄性恒河猴给予LHRH激动剂布舍瑞林进行治疗。同时通过硅橡胶胶囊给予睾酮。这种联合治疗导致睾丸体积显著减小，并且所有动物在治疗8 - 15周内均出现少精子症。然而，即使在治疗22周后仍未实现无精子症，尽管在之前一项单独给予LHRH激动剂的研究中，8 - 10周后就实现了无精子症。结论是，在这种灵长类动物中，补充睾酮会减弱LHRH激动剂输注对精子发生的抑制作用。
