Popov V G, Kiandzhuntseva E A, Gruzdev A K
Kardiologiia. 1983 Nov;23(11):98-103.
Acute experiments on 27 dogs were conducted to examine the effect of intravenous nitroglycerin, sodium nitroprusside and phentolamine on the hemodynamics and regional contractility of the left ventricle under conditions of experimental coronary occlusion. Nitroglycerin was the most effective agent versus the other drugs in decreasing the elevated diastolic pressure in the left ventricle whereas sodium nitroprusside showed the most pronounced hypotensive effect in relation to systemic arterial pressure. All these drugs produced indirect favourable chrono- and inotropic effects especially marked with phentolamine. The effect of nitroglycerin and sodium nitroprusside on the cardiac output may vary to a great extent: a decrease in the stroke volume occurred in the presence of the remaining high degree of peripheral vascular resistance and a fall in the elevated and diastolic pressure in the left ventricle, an increase in the stroke volume was observed in the case of a considerable drop in the overall peripheral vascular resistance and the persisting endodiastolic overburden of the left ventricle.
对27只狗进行了急性实验，以研究在实验性冠状动脉闭塞的情况下，静脉注射硝酸甘油、硝普钠和酚妥拉明对左心室血流动力学和局部收缩性的影响。与其他药物相比，硝酸甘油在降低左心室舒张压升高方面最为有效，而硝普钠对体循环动脉压显示出最显著的降压作用。所有这些药物都产生了间接的有利变时性和变力性作用，尤其是酚妥拉明的作用最为明显。硝酸甘油和硝普钠对心输出量的影响可能在很大程度上有所不同：在周围血管阻力仍处于较高水平且左心室舒张压升高时，每搏量会减少；而在总周围血管阻力显著下降且左心室舒张末期负荷持续存在时，则会观察到每搏量增加。
