Hawkey C J, Stirling Y, Chakrabarti R, Brozovic M, Cox A G, Meade T W
Thromb Res. 1983 Oct 15;32(2):223-7. doi: 10.1016/0049-3848(83)90033-6.
Changes in factors V, VII and VIII and in fibrinogen were studied in 32 patients undergoing major abdominal surgery. Mean levels of factors V and VII were similar to population-based values preoperatively. Factor V fell following elective surgery and then rose above the mean pre-operative level before returning to it by the tenth post-operative day. Factor VII fell following both elective and emergency surgery and tended to remain depressed throughout the post-operative period. Pre-operative values of factor VIII and fibrinogen were higher than population-based values and higher in the emergency than in waiting-list patients. Both factor VIII and fibrinogen rose following elective surgery but no statistically significant change was seen following emergency surgery. The uncomplicated conditions leading to elective surgery, the acute complications leading to emergency surgery, and surgery itself may each have contributed to increases in factor VIII and fibrinogen levels, whereas the fall in factors V and VII was largely related to surgery itself. The findings may help in the interpretation of associations between clotting factors and thrombotic disease, particularly in the case of factor VII.
对32例接受腹部大手术的患者的凝血因子V、VII和VIII以及纤维蛋白原的变化进行了研究。术前，凝血因子V和VII的平均水平与基于人群的值相似。择期手术后，凝血因子V水平下降，然后在术后第10天恢复到术前平均水平之前升至该水平之上。择期手术和急诊手术后，凝血因子VII均下降，且在术后整个期间往往持续处于较低水平。术前凝血因子VIII和纤维蛋白原的值高于基于人群的值，且急诊患者高于等待手术患者。择期手术后，凝血因子VIII和纤维蛋白原均升高，但急诊手术后未见统计学上的显著变化。导致择期手术的非复杂情况、导致急诊手术的急性并发症以及手术本身可能各自促成了凝血因子VIII和纤维蛋白原水平的升高，而凝血因子V和VII的下降在很大程度上与手术本身有关。这些发现可能有助于解释凝血因子与血栓性疾病之间的关联，尤其是凝血因子VII的情况。
