长效避孕剂：甾体酯的分析与纯化

Long-acting contraceptive agents: analysis and purification of steroid esters.

作者信息

Matlin S A, Chan L, Hadjigeogiou P, Prazeres M A, Mehani S, Roshdi S

出版信息

Steroids. 1983 Mar;41(3):361-7. doi: 10.1016/0039-128x(83)90107-1.

PMID:6419409

Abstract

More than 200 samples of esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) and levonorgestrel (13 beta-ethyl-17 alpha-ethynyl-17 beta-hydroxygon-4-en-3 -one) have been analysed by a combination of techniques, including high performance liquid chromatography (HPLC). Compounds having a purity below the required limit (99.5%) were purified, mainly by preparative HPLC, prior to formulation and biological evaluation as long-acting progestogens.

摘要

已通过包括高效液相色谱法（HPLC）在内的多种技术组合，对200多个炔诺酮（17α-乙炔基-17β-羟基雌甾-4-烯-3-酮）和左炔诺孕酮（13β-乙基-17α-乙炔基-17β-羟基孕甾-4-烯-3-酮）酯样品进行了分析。纯度低于规定限度（99.5%）的化合物在配制成长效孕激素并进行生物学评估之前，主要通过制备型HPLC进行纯化。