[Effect of the pesticide carbaryl (sevin) on the course of experimental Erysipelothrix rhusiopathiae infection in rats].

Rats treated with carbaril (sevin) at the rate of 2 to 5 mg were infected via the feed with Erysipelothrix rhusiopathiae in the course of 30 days. Studied were the clinical picture, some paraclinical indices, the mortality rate, and the morphologic and histopathologic changes in the parenchymal organs. It was found that rats that were given carbaril for a long time in minimum amounts and were then subjected to infection developed a characteristic clinical picture and showed a high mortality rate (nearly twice as high as that with the control animals). In hemocultures the causative agent was isolated over a longer period than in the case with the controls. Both the gross and the histopathologic findings were more strongly manifested in the test (carbaril-treated) rats.