色甘酸钠可抑制家兔因煤油气雾剂引起的支气管收缩。

Disodium cromoglycate inhibits bronchoconstriction by kerosine aerosol in rabbits.

作者信息

Casacó A, Arruzazabala L, González R, Rodríguez de la Vega A

出版信息

Allergol Immunopathol (Madr). 1983 Sep-Oct;11(5):335-7.

PMID:6419571

Abstract

To determine whether or not disodium cromoglycate (DSCG) inhibits the bronchoconstriction induced by inhalation of kerosene aerosol in rabbits, we carried out a study in 31 normal rabbits which were divided into four groups. DSCG was administered through the tracheal cannula twenty minutes before exposure to kerosene aerosol. Twenty and forty milligrams of DSCG as total doses inhibited kerosene induced bronchoconstriction in large airways (RL), but 5 mg of drug did not have any effect. DSCG at any tested dose did not inhibit the decreased dynamic lung compliance (CL) which was observed after kerosene aerosol. Our findings suggest that DSCG at high dose inhibit the bronchoconstrictor effect of kerosene in large airways of rabbits.

摘要

为了确定色甘酸钠（DSCG）是否能抑制兔吸入煤油气雾剂诱发的支气管收缩，我们对31只正常兔进行了一项研究，将其分为四组。在暴露于煤油气雾剂前20分钟，通过气管插管给予DSCG。总剂量为20毫克和40毫克的DSCG抑制了煤油诱发的大气道支气管收缩（RL），但5毫克药物没有任何作用。任何测试剂量的DSCG都没有抑制煤油气雾剂后观察到的动态肺顺应性（CL）下降。我们的研究结果表明，高剂量的DSCG可抑制兔大气道中煤油的支气管收缩作用。